Panstay-DSR Highlights

  • Excellent pain relief in ulcer healing: Pain relief achieved with Pantoprazole influences favborably as compared to Omeprazole and Lansoprazole.
  • Similar efficacy to Rabeprazole: Pantoprazole 40 mg/day and Rabeprazole 20 mg/day has similar efficacy in ulcer healing at 4-8 week treatment.
  • Better than Esomeprazole in GERD related symptoms: Pantoprazole resulted in significantly faster first time relief from day time and night time GERD related symptoms than Esomeprazole.
  • Pantoprazole:
    • Greater specificity for proton pump inhibition due to binding at the active site of the enzyme.
    • Longer durations of intragastric pH rise than omeprazole and other PPIs.
    • Effective in intra-esophageal acid suppression in non-erosive reflux disease (NERD) patients.
    • Effective over a full 24 hours and is well tolerated due to reduced potential for drug interactions.
    • Ensures greater relief in GERD-related symptoms in both day-time and night-time.
    • Pantoprazole is superior to ranitidine and as effective as omeprazole in the short term treatment of peptic ulcer and reflux oesophagitis, has shown efficacy when combined with antibacterial agents in H. pylori eradication, is apparently well tolerated and offers the potential advantage of minimal risk of drug interaction.
    • Patients with reflux esophagitis and H. pylori infection respond significantly better than H. pylori–negative patients to the PPI pantoprazole.
    • FDA approved short term therapy (7 to 10 days) for GERD.
    • Offers 85-95% supression in stomach acid secretion within 1 week of therapy.
    •  Excellent pharmacokinetic profile, with minimal range of drug drug interactions.
    • Treats pathological hypersecretory conditions associated with Zollinger-Ellison Syndrome or other neoplastic conditions.
    • Superior to ranitidine as an adjunct treatment to endoscopic injection therapy in high-risk bleeding ulcers.

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